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Recently we worked with a client who upgraded their Office to 2013 and ran into this error with editing a template in ACT. The full error was:
"Unable to cast COM object of type 'Microsoft.Office.Interop.Word.ApplicationClass' to interface type 'Microsoft.Office.Interop.Word._Application'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{00020970-0000-0000-C000-000000000046}' failed due to the following error: The RPC server is