If you ever get a Run-time error '-2146233088 when attempting to open Quotewerks, the error is telling you that you have not logged into Act. What often is going on is Act is sitting on another screen at the Logon menu. The menu may be hidden behind another application. Finish opening Act and then re-open Quotewerks.
Ever had the contact or group detail view empty on Act for Cloud or Act for Web? Then your web/browser cache is full. It doesn't have enough space to load the views.
Solution: Run History and Cache cleanup in your browser tools or settings.