Fixed this problem for a client and thought I'd post it here in case someone else is experiencing the same thing.
December 8, 2015, update for Outlook 2010 (KB3114409)
After you install this update, Outlook 2010 may start only in safe mode. If this issue occurs, uninstall the update. This update is no longer available now.
Microsoft has released an emergency patch for a critical flaw, affecting all supported versions of Windows. They said the vulnerability, if exploited, could "allow remote code execution if a user opens a specially crafted document or visits an untrusted webpage that contains embedded OpenType fonts.